Despite decades of computing advances, some human problems and core human values have remained difficult to solve or promote. Instead of advancing individual technologies, I focus our attention on making major leaps in system-level thinking and orchestration. Specifically, I describe my efforts to design, build, and study computational ecosystems that interweave effective practices, interactional structures, and intelligent systems to form new, integrative solutions. Computational ecosystems emphasize (1) combining wedges of human and machine intelligence to make effective practices feasible; and (2) creating processes, interactions, and communities that sustain and deepen practice. In the first half of my talk, I will share examples of computational ecosystems we built over the last decade that transform how we plan, coordinate, connect, learn, and innovate. The second half of my talk will share our more recent efforts to support human practices and human experiences computationally. I will close with a few thoughts on why we need computational ecosystems, especially if we intend to not only meet our consequentialist aims but to deepen our engagement in intrinsically valuable human activities.